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13. Lackner A, Cabral J, McNulty R. COMPOSITION AND METHODS FOR INHIBITING NOD-LIKE RECEPTOR PYRIN DOMAIN CONTAINING 3 (NLRP3) UC Ref. No.: 2024-928-1 NT Ref. No.: UCI 23.15 PROV Provisional Patent Application No.: 63/601,427

12. Lackner A, Cabral J, Qiu Y, Zhou H, Leonidas L, Pham MA, Macapagal A, Lin S, Armanus E, McNulty R†. Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation. BioRxiv 2023 (accepted)

11.  Angela Lackner, Yanfei Qiu, Emy Armanus, Alijah Nicholas Kahea Macapagal, Lemuel Leonidas, Huilin Xu, and Reginald McNulty. Measuring Interactions Between Proteins and Small Molecules or Nucleic Acids. Current Protocols 2024 (accepted)


10. Cabral J, Qiu Y, Yang Y, Heck AJ, and McNulty R†. Differential Large and Small Terminase Subunit Assembly Mediate Bacteriophage P22 Genome Packaging. Preprints 2023 (Under Review)

9.   Cabral A, Cabral J, Wang A, Zhang Y, Liang H, Nikbakht D,  Corona L, Hoffman H, McNulty R*†. Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Nature - Communications Biology 2023


8.   Cabral A, Cabral JE, McNulty R*†. Cryo-EM for small molecules. Current Protocols 2022

7.  Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020. Epub 2020/08/26. doi: 10.1038/s42255-020-0261-2. PMID: 32839596. PMC Journal In Process.

6.   McNulty R†, Cardone G, Gilcrease EB, Baker TS, Casjens SR, Johnson JE†. Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release. Biophys J. 2018;114(6):1295-301. doi: 10.1016/j.bpj.2018.01.026. PubMed PMID: 29590587; PMCID: PMC5883611.


5.   Mukherjee SP, Quintas PO, McNulty R, Komives EA, Dyson HJ. Structural characterization of the ternary complex that mediates termination of NF-kappaB signaling by IkappaBalpha. Proc Natl Acad Sci U S A. 2016;113(22):6212-7. doi: 10.1073/pnas.1603488113. PubMed PMID: 27185953; PMCID: PMC4896678.


4.   McNulty R*†, Lokareddy RK*, Roy A, Yang Y, Lander GC, Heck AJ, Johnson JE, Cingolani G†. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol. 2015;427(20):3285-99. doi: 10.1016/j.jmb.2015.08.013. PubMed PMID: 26301600; PMCID: PMC4587339.


3.   McNulty R, Ulmschneider JP, Luecke H, Ulmschneider MB. Mechanisms of molecular transport through the urea channel of Helicobacter pylori. Nat Commun. 2013;4:2900. doi: 10.1038/ncomms3900. PubMed PMID: 24305683; PMCID: PMC3863980.


2.   McNulty R*, Strugatsky D*, Munson K*, Chen CK, Soltis SM, Sachs G, Luecke H. Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori. Nature. 2013;493(7431):255-8. doi: 10.1038/nature11684. PubMed PMID: 23222544; PMCID: PMC3974264.


1.   McNulty R*, Nash AI*, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proc Natl Acad Sci U S A. 2011;108(23):9449-54. doi: 10.1073/pnas.1100262108. PubMed PMID: 21606338; PMCID: PMC3111320.


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